11 - Deoxycortisol
11 deoxycortisol is used in the diagnosis and monitoring of
congenital adrenal hypoplasia due to 11ß-hydroxylase deficiency.
The assay should be requested when CAH is suspected on clinical
grounds but serum 17-OH progesterone levels are equivocal. It is
analysed by Tandem mass spectrometry and a cortisol result is also
Run weekly in referral laboratory.
Collect at 09:00hrs as there is diurnal variation.
The patient must not be on steroids.
7 working days.
200 µL minimum volume is required.
Red topped Vacutainer serum or Lithium heparin plasma.
Separated and sent to a referral laboratory for analysis
(Wythenshaw Hospital, Manchester)
Causes for Rejection
Unlabelled or incorrectly labelled sample.
Taken at inappropriate time.
Request not justified.
See referral lab report form.