Adverse drug reaction
reaction, plasma tryptase
administration may cause immediate hypersensitivity (anaphylactic),
or histamine release (anaphylactoid) reactions. These may range
from minor (flushing, urticaria) to major (bronchospasm,
cardiovascular collapse). They are due to the release of histamine
and other vasoactive chemicals: they can be mimicked by other
conditions - underlying pathology or pharmacological effects.
Plasma tryptase (urine
methylhistidine is no longer available)
Request on ICE
Analysed by referral
laboratory if specific criteria met.
anaphylactic drug reaction.
Serum samples (SST or
red-top) are also acceptable.
Blood taken within 60
minutes, then 3 and 24 hours after reaction; separate,
purple-topped samples should be collected for FBC and
Measured at Southend
Pathology. If levels are raised, sample diluted on site