Part of Profile
Liver Function Test, Bone.
ALP rises in the presence of bile duct obstruction (e.g. primary
biliary cirrhosis, gallstones, bile duct strictures).
ALP is also elevated in bone disease where increased
osteoblastic activity is involved (e.g. malignancy (not myeloma),
Request on ICE
Serum in gold-top vacutainer
No specific collection conditions
Causes for Rejection
Unlabelled or incorrectly labelled sample; not meeting specific
criteria for analysis
Adult: 30 - 130 IU/L.
Mild increases in ALP may be seen as a result of age-related
changes, particularly in older women
Children: Refer to report for age-related reference range.
Levels in children may be mildly elevated during growth spurts.
Elevated ALP may be as a result of liver or bone disease.
Certain medications may also cause rises in ALP. A normal gamma-GT
may be used to exclude liver disease, but a raised gamma-GT does
not exclude bone disease (since liver and bone disease may both be
In bone disease, particularly high levels of ALP are seen
in Paget's disease. It should be noted that rises in ALP are not
seen in osteoporosis or myeloma as increased osteoblastic activity
is not involved.
In young children, high levels of ALP may be due to transient
hyperphosphatasaemia of childhood. Alkaline phosphatase
isoenzyme analysis may indicated in these cases.