Pathology Handbook

Angiotensin converting enzyme



Clinical Indications

Monitoring therapy on patients with known sarcoidosis. Serum ACE activity is raised in just over half of patients with sarcoidosis, reflecting the granulomatous load.  It may also be raised in other diseases with articular manifestations.  For these reasons it is NOT suitable as a screening test for sarcoidosis.

Request Form 

Request on ICE


Analysed by referral laboratory if specific criteria met.

Specific Criteria

Monitoring treatment in patients with diagnosed sarcoidosis

Turnaround Time

2 to 3 weeks

Patient Preparation

ACE inhibitors should be stopped for 12 hours prior to collection.


Serum in gold-top vacutainer


1 ml


Vacutainer gold top

Lab Handling

Sent to referral laboratory (Colchester Hospital)

Causes for Rejection

Unlabelled or incorrectly labelled sample; not meeting specific criteria for analysis

Reference Range

20 - 82 IU/L

Serum ACE levels are reduced in patients on ACE inhibitors