Aquaporin-4 antibodies NMO antibodies
Neuromyelitis optica (Devic's syndrome).
(specialist request only) Please
note: Antibodies are specific for neuromyelitis optica (NMO);
their detection forms part of the diagnostic criteria for this
condition. This antibody is found in about 65% of patients with
Detection of IgG antibodies against cerebellar, midbrain and
spinal cord tissue by indirect immunofluorescence.
Request via ICE
Assay is performed weekly.
It is essential to provide relevant clinical information.
No special preparation is required.
All samples are generally sent to referral
laboratory within 3 working days of receipt in the
laboratory. Samples are batched and the assay is performed twice
Serum in red top tube
Gold top (SST) tube will be accepted
Samples should be transported to the laboratory as soon as is
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Causes for Rejection
Unlabelled/inadequately labelled sample.
Inadequately completed request form.
Delay in sample reaching laboratory.
Samples are tested for the presence of antibodies against
aquaporin-4 by indirect immunofluorescence and the result reported
as Positive or Negative.