N-terminal pro-b-type natriuretic peptide
Pro B-type natriuretic peptide (BNP) is released from the
cardiac ventricles in response to stretching of the chamber and is
cleaved to form biologically active BNP and N-terminal pro-BNP
(NT-proBNP). The assay used at Southend measures NT-proBNP.
It has been introduced to 'rule-out' suspected heart failure and
help select patients requiring cardiac imaging. It is important
that it is only requested in patients meeting specific criteria
(see below), otherwise many 'false positive' results may be
generated which will need follow-up cardiac imaging.
Request on ICE
Only available to GPs
BNP analyses is only available for investigation
of new cases of suspected heart failure. ECG and
chest X-ray should have been undertaken and anaemia, renal, liver
and thyroid dysfunction excluded.
Serum in gold-top vacutainer
Causes for Rejection
Unlabelled or incorrectly labelled sample; not meeting specific
criteria for BNP requesting.
Males: <100 pmolL
Females <150 pmol/L
If levels exceed the cut-off recommended by Cardiology, the
patient will automatically be referred for an echocardiogram