Pathology Handbook

C. diff toxin

Synonyms

 -

Clinical Indications

Post antibiotic therapy, patient >65 years of age, suspected pseudomembranous colitis, hospital in patient >3 days

Test Includes

Detection of Clostridium difficile toxins A and B in faeces

Request Form

ICE request

Availability

On request during routine working hours

Specific Criteria

Please give detailed clinical information including: details of any recent, current, or intended, antibiotic therapy; date of onset/contact with any suspected infection

Turnaround Time

The test will usually be performed on day of receipt of the sample

Specimen

Faeces; formed stools will not be tested

Volume

A walnut-sized portion should be submitted in a faeces container

Container

Large white capped universal container 

Large white top universal

Collection

Samples should be transported to laboratory as soon as possible

Causes for Rejection

Unlabelled / inadequately labelled sample
Delay in sample reaching laboratory
Leaking sample

If a positive result is obtained further samples will not be tested until 21 days after the collection date of the original positive sample unless a new episode of diarrhoea
If a negative result is obtained further samples will not be tested until 14 days after the collection date of the original negative sample unless a new episode of diarrhoea or there is a strong suspicion of C. difficile infection.

Reference Range

 -

Lab Handling

Samples should be processed on day of receipt