C-reactive Protein (CRP)
C-Reactive Protein (CRP) is the most sensitive acute phase
protein and is the assay of choice in most situations when
detection or monitoring of the acute phase response is required.
CRP is specific for the acute phase response and
unlike ESR is not elevated due to other causes. It has a
rapid response time and will rise within two hours of acute insult
(surgery, infection, etc.). CRP has a short half life (8 hours) and
should peak and begin decreasing within 48 hours if no other
inflammatory event occurs. It's catabolism is not affected by the
type of inflammation.
Request on ICE
Causes for Rejection
Unlabelled or incorrectly labelled sample
Adult: less than 8 mg/L
Up to 1 month: less than 6 mg/L
Most patients (90%) without organic disease have CRP levels less
than 3mg/L and 99% have levels less than 10mg/L. Neonates are
unable to induce CRP synthesis to the same extent and the neonatal
reference range is lower.
Slightly higher CRP levels may be found in pregnancy, but any
increase is usually within the reference range quoted.