Carbohydrate Antigen 15-3
Serum CA15-3 is raised in breast and other adenocarcinomas,
especially with distant metastasis. Levels are rarely raised in
patients with localised breast cancer.
Request on ICE
Analysed by referral laboratory if specific criteria met.
ONLY for monitoring treatment of patients with advanced breast
cancer on request by a Consultant Oncologist.
Must not be used for screening for
NOTE: If a patient is having serial tumour marker levels
monitored the tests must all be done at the same laboratory as
there are significant variations between assays
Sent to referral laboratory (Charing Cross)
Causes for Rejection
Unlabelled or incorrectly labelled sample; not meeting specific
criteria for analysis.
Less than 32 kU/L
Half-life in Serum
CA15-3 levels may be raised in benign liver disease and possibly
benign breast disease. Elevations are seen in a number of
carcinomas e.g. stomach, colon, gall bladder, pancreas, oesophagus,
liver and lung.