Pathology Handbook

Caeruloplasmin

Clinical Indications

Low caeruloplasmin is found in most cases of Wilson's disease. Copper accumulation produces clinical features (hepatic disease, neurological signs, Kayser-Fleischer rings) usually in late childhood / early adulthood. 

Decreased levels also found in severe liver disease.

Request Form

Request on ICE

Availability

Analysed by referral laboratory if specific criteria met.

Specific Criteria

Investigation of suspected Wilson's disease

Turnaround Time

2 weeks

Specimen

Serum

Volume

2 ml

Container

Vacutainer gold top

Lab Handling

Sent to referral lab (Royal Surrey County Hospital)

Causes for Rejection

Unlabelled or incorrectly labelled sample; not meeting specific criteria for analysis; inadequate clinical information. 

Reference Range

Adult 0.2 - 0.6 g/L

Up to 4 months 0.09 - 0.27 g/L

4 months to 1 year 0.14 - 0.41 g/L