Low caeruloplasmin is found in most cases of Wilson's disease.
Copper accumulation produces clinical features (hepatic disease,
neurological signs, Kayser-Fleischer rings) usually in late
childhood / early adulthood.
Decreased levels also found in severe liver disease.
Request on ICE
Analysed by referral laboratory if specific criteria met.
Investigation of suspected Wilson's disease
Sent to referral lab (Royal Surrey County Hospital)
Causes for Rejection
Unlabelled or incorrectly labelled sample; not meeting specific
criteria for analysis; inadequate clinical information.
Adult 0.2 - 0.6 g/L
Up to 4 months 0.09 - 0.27 g/L
4 months to 1 year 0.14 - 0.41 g/L