Faecal calprotectin is a neutrophil marker protein that gives an
objective measure of inflammation in inflammatory bowel disease
(IBD), i.e. ulcerative colitis and Crohn's disease.
Calprotectin is a non-specific marker of gastrointestinal disease
of both inflammatory and neoplastic character and its high
sensitivity and negative predictive values can be useful to select
patients for colonoscopy.
It may also be useful for early detection of relapse in IBD and
monitoring disease activity and response to treatment.
There are several known causes of falsely raised calprotectin
levels. These are:
• NSAID treatment (excluding low dose aspirin circa 75mg)
• Systemic malignancy
• Cirrhosis of the liver
• Shingles, salmonella and c. diff infections
Request on ICE or use combined Biochemistry/Haematology form
Analysed by referral laboratory if specific criteria met.
Requested by Consultant Gastroenterologist and agreed with
Calprotectin is evenly distributed in stools so that only a
small stool sample is required for analysis.
Sent to referral laboratory (Basildon Hospital)
Causes for Rejection
Not meeting specific criteria for analysis.
For results between 0-110 ug/g faeces: Normal faecal
calprotectin ?IBS or quiescent IBD.
For results between 110-1800 ug/g faeces: Raised faecal
calprotectin may indicate IBD. Mildly raised figures may still be
normal. Also consider other causes e.g. infection, polyps,
malignancy and NSAID use.