Pathology Handbook

Cardiac Muscle Antibodies

Clinical Indications

Dressler's syndrome post myocardial infarct (MI)

Please note: These antibodies have also been found in patients with myocarditis, dilated cardiomyopathy and rheumatic carditis.

Test Includes

The detection of IgG autoantibodies against adenine nucleotide translocator protein, cardiac myosin and tropomyosin.

Request Form 

Request via ICE


Assay is performed weekly.

Specific Criteria

It is essential to provide relevant clinical information.

Patient Preparation

No special preparation is required.

Turnaround Time

All samples are generally sent to referral laboratory within 3 working days of receipt in the laboratory. Samples are batched and the assay is performed twice per week.


Serum in red top tube

Gold top (SST) tube will be accepted


7 ml


Vacutainer red top


Samples should be transported to the laboratory as soon as is practicably possible.

Lab Handling

Aliquot and store at 4-8°C prior to testing and at -20°C or below for up to 1 month after receipt.

Causes for Rejection

Unlabelled/inadequately labelled sample.

Inadequately completed request form.

Delay in sample reaching laboratory.

Reference Range

Samples are tested for the presence of anti Cardiac Muscle antibodies by indirect immunofluorescence and the result reported as Positive or Negative.