Pathology Handbook

CCP Antibodies


Cyclic Citrullinated Peptide

Clinical Indications

Rheumatoid Arthritis (RA)

Please note: This assay is very specific (>95%) and sensitive (60 - 77%) for RA. It can aid early diagnosis, especially in patients with undifferentiated arthritis, and the presence of these antibodies is linked with a more aggressive disease.

Test Includes

Detection of IgG antibodies directed against a number of citrulllinated synthetic peptides.

Request Form 

Request via ICE


Assay performed daily Monday to Friday.

Specific Criteria

It is essential to provide relevant clinical information.

Patient Preparation

No special preparation is required.

Turnaround Time

All samples are generally sent to referral laboratory within 3 working days of receipt in the laboratory. Samples are batched and the assay is performed twice per week.


Serum in red top tube

Gold top (SST) tube will be accepted


7 ml


 Vacutainer red top


Samples should be transported to the laboratory as soon as is practicably possible.

Lab Handling

Aliquot and store at 4-8°C prior to testing and at -20°C or below for up to 1 month after receipt.

Causes for Rejection

Unlabelled/inadequately labelled sample.

Inadequately completed request form.

Delay in sample reaching laboratory.

Reference Range

Negative: <7 U/mL

Equivocal: 7 - 10 U/mL

Positive: >10 U/mL