Chromogranin A and B
Chromogranin A is produced by a variety of normal and malignant
neuroendocrine and sympathetic neuronal cells and may serve as a
clinically useful marker for hormone-negative endocrine
Elevated levels of Chromogranin A are seen in neuroendocrine
tumours, including phaeochromocytoma, medullary carcinoma of
thyroid, pancreatic islet cell adenoma, carcinoid tumour, anterior
pituitary adenoma, carotid body tumour, small cell carcinoma of the
lung and neuroblastoma.
Minor increases are seen in essential hypertension. Chromogranin
A concentrations rise markedly in patients with renal failure.
Please note that spuriously high levels of Chromogranin A have
been reported in patients taking proton pump inhibitors
Request on ICE
Analysed by referral laboratory if specific criteria met.
Investigation of suspected neuroendocrine tumour, if
specifically requested by a Consultant.
EDTA (lemon top)
Sent to referral laboratory (Hammersmith Hospital)
Causes for Rejection
Unlabelled or incorrectly labelled sample; not meeting specific
criteria for analysis; incorrectly collected sample.
Chromogranin A <60 pmol/L
Chromogranin B <150 pmol/L