Pathology Handbook

Collagen Type 2 Antibodies

Clinical Indications

Relapsing polychondritis Early Rheumatoid Arthritis (RA). Please note: Antibody levels possibly correlate with disease activity.

Test Includes

Detection of IgG antibodies to Type II Collagen.

Request Form 

Request via ICE


Assay performed as required.

Specific Criteria

It is essential to provide relevant clinical information.

Patient Preparation

No special preparation is required.

Turnaround Time

All samples are generally sent to  referral laboratory within 3 working days of receipt in the laboratory. The assay is performed as required.


Serum in red top tube

Gold top (SST) tube will be accepted


7 ml


Vacutainer red top 


Samples should be transported to the laboratory as soon as is practicably possible.

Lab Handling

Aliquot and store at 4-8°C prior to testing and at -20°C or below for up to 1 month after receipt.

Causes for Rejection

Unlabelled/inadequately labelled sample.

Inadequately completed request form.

Delay in sample reaching laboratory.

Reference Range

Samples are tested for the presence of antibodies to collagen type II by indirect immunofluorescence and the result reported as Positive or Negative.