Pathology Handbook

CSF - Neurodegenerative screen

Synonyms

 -

Clinical Indications

CSF neurodegenerative screen consists of CSF S100 beta, CSF Total Tau, CSF A-Beta 1-42 and CSF phosphorylated Tau as markers for the investigation of possible Alzheimer's disease in non-typical patients. They reflect the presence of neurofibrillary tangles and neurodegeneration.

Request Form 

Request on ICE

Availability

On request

Specific Criteria

Investigation of possible Alzheimer's disease in young patients or those without a typical presentation or history.

Turnaround Time

1 month

Specimen

CSF must be collected into a polypropylene Universal tube and sent to Pathology immediately

Volume

Minimum CSF volume is 800 ul ( the referral lab require 3 separate aliquots of 250 ul)

Container

30 ml polypropylene Universal tube, available on Neurology Ward and from Pathology

Lab Handling

Separate into 3 labelled polypropylene separation tubes (either 1.2 ml SAS pots or PTH pots). Store at -80 until despatch. Despatch to referral lab on dry ice by courier.

Referral labs is the Neuroimmunology and CSF laboratory, The National Hospital for Neurology and Neurosurgery

Causes for Rejection

Collected into wrong container. Not a request from Neurology

Interpretation

See referral laboratory report