CSF - Neurodegenerative screen
CSF neurodegenerative screen consists of CSF S100 beta, CSF
Total Tau, CSF A-Beta 1-42 and CSF phosphorylated Tau as markers
for the investigation of possible Alzheimer's disease in
non-typical patients. They reflect the presence of neurofibrillary
tangles and neurodegeneration.
Request on ICE
Investigation of possible Alzheimer's disease in young patients
or those without a typical presentation or history.
CSF must be collected into a polypropylene Universal tube and
sent to Pathology immediately
Minimum CSF volume is 800 ul ( the referral lab require 3
separate aliquots of 250 ul)
30 ml polypropylene Universal tube, available on Neurology Ward
and from Pathology
Separate into 3 labelled polypropylene separation tubes (either
1.2 ml SAS pots or PTH pots). Store at -80 until despatch. Despatch
to referral lab on dry ice by courier.
Referral labs is the Neuroimmunology and CSF laboratory, The
National Hospital for Neurology and Neurosurgery
Causes for Rejection
Collected into wrong container. Not a request from Neurology
See referral laboratory report