Ciclosporin, Cyclosporine A
Therapeutic drug monitoring of patients on cyclosporin after
Sub-therapeutic levels may result in organ rejection and high
levels in renal damage.
In patients on long-term follow-up, it is important to use the
same assay on each occasion - we must therefore be told where the
patient had their transplant done so that the samples can be sent
to the appropriate laboratory.
Levels are also of value in patients on cyclosporin for
Request on ICE
Give details of WHERE the patient had their
transplant so that samples can be sent to the most appropriate
Monitoring of patients on cyclosporin therapy
Samples should be collected before next dose (trough)
Whole blood in Biochemistry EDTA tube
Sent to referral laboratory; the laboratory used depends on
where the patient received their transplant as results are not
always transferable between different laboratories.
Causes for Rejection
Therapeutic range varies depending on reasons for use, type and
age of transplant, and concomitant disease and
medication. Renal and liver function should also be
Therapeutic range 100 - 300 ng/mL. Potentially toxic >400