Pathology Handbook

DHEA-S

Synonyms

Dehydroepiandrosterone sulphate, DHEA, DHAS

Clinical Indications

DHEA-S is useful in the diagnosis of a virilizing adrenal tumour and to monitor recurrence after surgical removal. It is also useful in the further investigation of a raised testosterone in a woman, but is of little value in the investigation of acne, idiopathic hirsuitism or infertility.
DHEA-S is the first adrenal androgen to show a significant increase at the onset of adrenarche and serum levels give an indication of the stage of development in children and may be useful in the investigation of delayed or precocious adrenarche / puberty.

Request Form

Request on ICE

Availability

On request

Specific Criteria

Diagnosis / monitoring of virilizing adrenal tumour.  Investigation of delayed or precocious adrenarche / puberty.

Turnaround Time

Weekly

Specimen

Serum

Volume

1 ml

Container

Vacutainer gold top

Collection

After surgery samples should be taken as soon as practicable and at least every 2 months thereafter to monitor for recurrence.

Causes for Rejection

Unlabelled or incorrectly labelled sample; collected into EDTA or heparin tube.

Reference Range

Age DHEA-S (┬Ámol/L) DHEA-S (┬Ámol/L)
  Female Male
20 to 29 years 1.8 - 10.3 7.6 - 17.4
30 to 39 years 1.2 - 7.3 3.3 - 14.1
40 to 49 years 0.9 - 6.5 2.6 - 14.4
50 to 59 years 0.8 - 5.4 1.9 - 8.4
60 to 69 years 0.4 - 3.5 1.1 - 7.9
70 to 79 years 0.5 - 2.4 0.8 - 4.8