Pancreatic elastase 1 (E1), a digestive protease, is synthesised
by the acinar cells of the pancreas. Levels of E1 in faeces may be
used as a non-invasive method to assess exocrine pancreatic status
in patients with Cystic Fibrosis.
Request on ICE or use combined Biochemistry/Haematology form
Analysed by referral laboratory if specific criteria met.
Requested by Consultant Paediatrician or if agreed with
Consultant Biochemist for patients with Cystic Fibrosis
The assay is highly specific for human pancreatic E1 and
patients do not need to stop taking pancreatic
supplements before assessment of pancreatic exocrine function.
Random faecal sample
Store at 4C. Samples should sent by 1st class post or
Sent to referral laboratory (Southampton General Hospital)
Causes for Rejection
Not meeting specific criteria for analysis.
Normal levels: 100-200 µg/g faeces
Severe exocrine pancreatic insufficiency: < 100 µg/g