Glutamic Acid Dehydrogenase antibodies
Type I autoimmune diabetes mellitus (IDDM) Latent autoimmune
diabetes in adults (LADA) First degree relatives of patients with
Type I diabetes Stiff Person Syndrome (SPS) Please note: Anti GAD
antibodies are found in 65 - 85% of patients with Type I Diabetes,
in 70 - 90% of patients with LADA, approximately 80% of healthy
relatives of patients with Type I Diabetes and a small percentage
of patients with Type II Diabetes. Levels are generally low in
Diabetes (<100 U/mL). Anti GAD antibodies are found in
approximately 60% of patients with Stiff Person Syndrome. Levels
are generally high in SPS (>300 U/mL).
Detection of IgG antibodies to Glutamic acid Dehydrogenase.
Request via ICE
Assay is performed weekly.
It is essential to provide relevant clinical information.
No special preparation is required.
All samples are generally sent to referral
laboratory within 3 working days of receipt in the
laboratory. Samples are batched and the assay is performed once per
Serum in red top tube
Gold top (SST) tube will be accepted
Samples should be transported to the laboratory as soon as is
Causes for Rejection
Unlabelled/inadequately labelled sample
Inadequately completed request form
Delay in sample reaching laboratory.
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Results shoulf be interpreted as follows
Negative result is 0-5.0 U/ml
Equivocal result is 5.1-25.0 U/ml
Positive result is >25.0 U/ml