Pathology Handbook

Ganglioside antibodies - GM1

Clinical Indications

Guillaine Barre Syndrome (GBS)

Multifocal motor neuropathies

Motor Neurone Disease (MND)

Chronic Inflammatory Demyelinating Polyneuropathy (CIPD)

Please note: Antibodies to GM1 are seen in up to 50% of patients with multifocal neuropathy and less frequently in GBS. The antibody is found in up to 25% of patients with MND.

Test Includes

Detection of IgG and IgM antibodies against membrane ganglioside M1

Request Form 

Request via ICE

Availability

Assay performed fortnightly.

Specific Criteria

It is essential to provide relevant clinical information.

Patient Preparation

No special preparation is required.

Turnaround Time

All samples are generally sent to referral laboratory within 3 working days of receipt in the laboratory. Samples are batched and the assay is performed once per week.

Specimen

Serum in red top tube

Gold top (SST) tube will be accepted

Volume

7 ml

Container

Vacutainer red top

Collection

Samples should be transported to the laboratory as soon as is practicably possible.

Causes for Rejection

Unlabelled/inadequately labelled sample

Inadequately completed request form

Delay in sample reaching laboratory.

Laboratory Handling 

Aliquot and store at 4-8°C prior to testing and at -20°C or below for up to 1 month after receipt.

Reference Range

A qualitative result is given and samples are reported as Positive, or Negative