Ganglioside antibodies - GM1
Guillaine Barre Syndrome (GBS)
Multifocal motor neuropathies
Motor Neurone Disease (MND)
Chronic Inflammatory Demyelinating Polyneuropathy (CIPD)
Please note: Antibodies to GM1 are seen in up to 50% of
patients with multifocal neuropathy and less frequently in GBS. The
antibody is found in up to 25% of patients with MND.
Detection of IgG and IgM antibodies against membrane ganglioside
Request via ICE
Assay performed fortnightly.
It is essential to provide relevant clinical information.
No special preparation is required.
All samples are generally sent to referral
laboratory within 3 working days of receipt in the
laboratory. Samples are batched and the assay is performed once per
Serum in red top tube
Gold top (SST) tube will be accepted
Samples should be transported to the laboratory as soon as is
Causes for Rejection
Unlabelled/inadequately labelled sample
Inadequately completed request form
Delay in sample reaching laboratory.
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
A qualitative result is given and samples are reported as
Positive, or Negative