Diagnosis of the Zollinger-Ellison syndrome (gastrin-producing
Part of Profile
May be part of Gut Hormone profile
Request on ICE
Analysed by referral laboratory if specific criteria met.
Agreed with Consultant Biochemist. Please provide details of all
drugs currently administered, details of any gastric surgery, basal
and stimulated acid output.
Patient should be fasting. H2 antagonists should be
stopped for 72 hours, and omeprazole for 2 weeks.
Plasma collected into lemon-top EDTA tube
Samples MUST ONLY be collected at Southend Hospital
Samples must be transported to laboratory immediately.
Sent to referral laboratory (Hammersmith Hospital)
Separate the plasma in a refrigerated centrifuge and freeze
within 15 minutes of venepuncture.
Causes for Rejection
Unlabelled or incorrectly labelled sample; delay in sample
receipt; haemolysis invalidates the result.
Less than 40 pmol/L
The most common cause of an increased gastrin is a slight degree
of gastritis and relative hypochlorhydria. Thus gastric secretory
studies must be done before making a diagnosis of gastrinoma.
Levels are raised in renal failure