Glomerular Basement Membrane Antibodies
Rapidly progressive glomerulonephritis (RPGN)
Acute renal failure
Please note: Early diagnosis is important as untreated
patients will suffer extensive tissue damage which in extreme cases
may result in death. It has been noted that 10-35% of patients with
anti GBM antibodies also have anti-neutrophil antibodies
Detection of IgG antibodies against the non-collagenous portion
of type IV collagen.
Request via ICE
Assay is performed daily as required.
It is essential to provide relevant clinical information.
It is essential to inform the laboratory by telephone of any
No special preparation is required.
All tests are performed on the next routine working day after
receipt of the sample.
Serum in red top tube
Gold top (SST) tube will be accepted
Samples should be transported to the laboratory as soon as is
Causes for Rejection
Unlabelled/inadequately labelled sample
Inadequately completed request form
Delay in sample reaching laboratory.
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Samples will be tested for the presence of anti GBM by Enzyme
Negative <20 U/mL
Positive >20 U/mL