Luteinising Hormone (LH) and Follicle Stimulating Hormone
LH and FSH are anterior pituitary hormones which regulate male
and female gonadal function. Measurement of LH/FSH can be useful in
suspected disorders of gonadal function.
LH / FSH
Request on ICE
Investigation of suspected hypothalamic, pituitary or gonadal
If the sample is for ?menopause ONLY an FSH is required
LH & FSH are suppressed in patients taking the combined oral
contraceptive pill and there is no point in measuring gonadotrophin
levels under these circumstances
Same Day (Monday to Friday)
If patient is having menstrual cycles, collect between days 1 to
5 of cycle
Causes for Rejection
Unlabelled or incorrectly labelled sample
In women, dependent on stage of menstrual cycle; in the early
follicular phase, and in men, levels of LH and FSH are usually
Low LH/FSH: pituitary / hypothalamic disease.
High gonadotrophins: primary gonadal failure (LH and FSH),
azoospermia / ovulatory failure (FSH), polycystic ovary syndrome
Towards the menopause, FSH tends to rise before LH, although both
show considerable variation. After the menopause, levels of both
FSH and LH are greatly elevated (greater than 28 U/L).