White cell antibodies
To determine granulocyte antibody significance in patients
with severe neutropenia (cause unknown )
NBS request form (3E) completed in conjunction with the
laboratory following discussion with Consultant
Analysed by Reference Laboratory (NBS) if specific criteria met.
Requested by Consultant or agreed with Consultant
Usually within two months
As requested by NBS specific to specialist investigation
required. Requestor will be advised on a case by case basis
Samples should be transported to laboratory immediately
Causes for Rejection
Unlabelled /unsigned sample. Incorrect or inadequate patient
identifiers provided. Insufficient sample volume. Poor sample
quality due to deterioration, haemolysis, presence of clot
Testing for Granulocyte antibodies will only be undertaken
if the condition falls into the following categories.
- Autoimmune neutropenia, caused by rare granulocyte
autoantibodies. The condition in children between 6 months and 5
years, known as autoimmune neutropenia of infancy, is self limiting
but may last several years. In adults, the condition may present as
an isolated primary disorder or be secondary to other conditions
such as rheumatoid arthritis or SLE.
- Neonatal neutropenia, caused by maternal antibodies present on
granulocytes at birth, leading to the risk of infectious
- Severe non haemolytic transfusion reactions.
- Transfusion related acute lung injury (TRALI)
- Neutropenia following bone marrow transplant.
- Drug induced antibody neutropenia. This test must be
accompanied by a sample of the drug involved