Haemaglobinopathy screen (not antenatal)
Thalassaemia screen, Sickle screen, Haemoglobin variant
To confirm or exclude presence of haemoglobin variant and or
HPLC, FBC ; if indicated : Sickle solubility test,
cellulose acetate electrophoresis and Kleihauer film
Part of Profile
Request on ICE
On request; daily routine working day
Ethnic origin required
Genetic counselling must be considered
Generally 3 days this may be extended if confirmatory testing is
Purple top (EDTA) tube
Causes for Rejection
Incorrect sample identification, clotted, inadequate, grossly
Previously reported (x2) Haemoglobinopathy
See patient test report.
A haemoglobin variant may be detected through routine diabetic
screening and HbA1C analysis. A report of the variant will be
issued with the HbA1C result and where appropriate an alternative
method of diabetic monitoring will be suggested.
Results of infants must be discussed with Consultant
A low or equivocal serum ferritin level can falsely lower the
HbA2 level. Ferritin stores should be restored before repeat
testing is performed.
Rare Hb variants requiring confirmation or requiring definitive
diagnosis will be sent to Kings College Hospital. Contact lab first
if DNA/globin chain analysis is required.