Drug induced SLE
Please note: Histone antibodies are found
in 95% of patients with drug induced SLE. Antibodies are also found
in SLE and RA.
Detection of IgG antibodies against histones.
Request via ICE
Assay is performed weekly.
It is essential to provide relevant clinical information.
No special preparation is required.
All samples are generally sent to referral
laboratory within 3 working days of receipt in the
laboratory. Samples are batched and the assay is performed once per
Red top tube.
Gold top SST tube will be accepted.
Samples should be transported to the laboratory as soon as is
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Causes for Rejection
Unlabelled/inadequately labelled sample
Inadequately completed request form
Delay in sample reaching laboratory.
Samples are tested for the presence of histone antibodies by
Enzyme Immunoassay and the results reported as Positive or