Insulin-like Growth Factor 1,
Screening for acromegaly. An elevated IGF-1 in a patient with
the appropriate clinical picture is diagnostic. Occasionally
acromegalics may have a normal IGF-1 level at diagnosis so a growth
hormone suppression test remains the definitive diagnostic
Follow up of treatment for acromegaly. IGF-1 should be measured
annually along with growth hormone. Elevated IGF-1 with
normal growth hormone levels may indicate a need for further
lowering growth hormone levels.
Request on ICE
Requested by Consultant Endocrinologists or if agreed with
Samples must be transported to laboratory immediately.Patients
must be bled at Southend Hospital.
Separate immediately and freeze at minus 20C. Sample sent to
referral laboratory (Guildford).
Causes for Rejection
Unlabelled or incorrectly labelled sample; not meeting specific
criteria for analysis; delay in sample reaching laboratory.
Please note the IGF1 assay changed from Siemens to IDS
iSYS on the 01/02/2013 and the units have changed from ng/L to
nmol/L since this date.
Please refer to the laboratory report for the reference range as
these are now age and sex related.