Serum LDH is increased in many malignancies. Mild to
moderate increases probably reflect tissue destruction but very
high levels (>2,000 IU/L) may be seen in patients with lymphoma
or leukaemia and in certain cancers of ovary or testis. Some solid
tumours (e.g. lung, colon, stomach) may occasionally produce very
high levels of LDH.
The test should has no role in the diagnosis of myocardial
Request on ICE
On request if specific criteria met.
Monitoring of therapy in lymphoma or leukaemia as a marker of
cell proliferation. LDH may also be used as a marker is some cases
of ovarian and testicular germ cell tumours and assessment of
melanoma and renal cell carcinoma.
Haemolysis will artefactually increase levels.
Causes for Rejection
Unlabelled or incorrectly labelled sample; not meeting specific
criteria for analysis; haemolysed sample. Result supressed when
haemolysis index > 60
240 - 480 U/L
Note that different laboratories use different methods for
measuring LDH and results are NOT transferable between
In patients on chemotherapy who are receiving granulocyte colony
stimulating factor, LDH levels may increase in parallel with white
cell count and should not be taken as evidence of worsening
Increased levels of LDH may occur in a number of benign conditions
including skeletal muscle disease, myocardial infarction,
pernicious anaemia, thalassaemia and pulmonary embolism.