M2 Mitochondrial Antibodies
Primary Biliary Cirrhosis (PBC)
Autoimmune Chronic Active Hepatitis
Please note: M2 antibodies are strongly associated with PBC
in >95% of cases. The antibody is also found in chronic liver
disease (30%) and Systemic Sclerosis (15%).
Detection of IgG antibodies against the E2 component of the
pyruvate dehydrogenase complex.
Request via ICE.
Assay performed when sufficient samples received.
It is essential to provide relevant clinical information.
No special preparation is required.
All samples are generally sent to referral
laboratory within 3 working days of receipt in the
laboratory. The assay is performed when sufficient samples are
Red top tube. Gold top tube will be accepted.
Samples should be transported to the laboratory as soon as is
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Causes for Rejection
Unlabelled/inadequately labelled sample.
Inadequately completed request form.
Delay in sample reaching laboratory.
A qualitative result is given and samples are reported as
Positive, Weak Positive or Negative.