MI 2 Antibodies
(Specialist request only)
Please note: Mi-2 antibody is seen in 25% of adults with
Dermatomyositis, in 10-15% of patients with Juvenile
Dermatomyositis and in less than 1% of patients with polymyositis.
MI-2 antibodies are generally of high titre, and show no variation
during the course of the disease or its treatment.
Detection of IgG autoantibodies against the saline extracted
cellular antigen Mi-2.
Request via ICE.
Assay is performed as required.
It is essential to provide relevant clinical information.
No special preparation is required.
All samples are generally sent to referral
laboratory within 3 working days of receipt in the
laboratory. The assay is performed as required.
Red top tube. Gold top tube will be accepted.
Samples should be transported to the laboratory as soon as is
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Causes for Rejection
Unlabelled/inadequately labelled sample.
Inadequately completed request form.
Delay in sample reaching laboratory.
A qualitative result is obtained and samples are reported as
Positive or Negative.