MPO & PR3 antibodies
Autoimmune vasculitides including:
Please note: All samples found to be ANCA IIF positive or to have
an interfering ANA will be tested for the presence of MPO and PR3
The assay should not be considered diagnostic and a definitive
diagnosis should not be based on the results of this assay
Detection of IgG autoantibodies against myeloperoxidase and
Request via ICE
Assay performed daily; Monday to Friday.
It is essential to provide relevant clinical information.
It is essential to inform laboratory by telephone of any urgent
All tests are performed on the next routine working day after
receipt of the sample.
Red top tube
Samples should be transported to the laboratory immediately
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Causes for Rejection
Unlabelled/inadequately labelled sample
Inadequately completed request form
Delay in sample reaching laboratory
Negative: MPO <3.5 IU/mlPR3 <2 IU/ml
Equivocal: MPO 3.5-5.0 IU/ml PR3 2-3 IU/ml
Positive: MPO >5.0 IU/mlPR3 >3 IU/ml