Acetylcholine receptor antibody negative myasthenia gravis
(Specialist request only)
Please note: Approximately 15% of patients with Myasthenia
gravis are negative for acetylcholine receptor antibodies (AChR).
Up to 50% of these AChR negative patients will have MuSK
Detection of IgG antibodies to muscle-specific receptor tyrosine
Request via ICE.
Assay performed weekly.
It is essential to provide relevant clinical information.
No special preparation is required.
All samples are generally sent to referral
laboratory within 3 working days of receipt in the
laboratory. Samples are batched and the assay is performed
Red top tube. Gold top tube will be accepted.
Samples should be transported to the laboratory as soon as is
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Causes for Rejection
Unlabelled/inadequately labelled sample.
Inadequately completed request form.
Delay in sample reaching laboratory.
A qualitative result is given and samples are reported as
Positive or Negative.