Neuronal Nuclear Antibody – Anti CRMP/CV2 antibodies
(specialist request only)
Please note: This antibody is found in approximately 70% of
patients with Paraneoplastic Neurological Syndromes (PNS) in
association with lung carcinomas (mostly SCLC) and 6% of patients
with PNS with thymoma. It is also found in PNS patients with
various other tumours.
Detection of autoantibodies against antigens in the cytoplasm of
Request via ICE.
Assay performed weekly.
It is essential to provide relevant clinical information.
No special preparation is required.
All samples are generally sent to referral
laboratory within 3 working days of receipt in the
laboratory. The assay is performed as required.
Serum in red top tube
Gold top (SST) tube will be accepted
Samples should be transported to the laboratory as soon as is
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Causes for Rejection
Unlabelled/inadequately labelled sample
Inadequately completed request form
Delay in sample reaching laboratory.
A qualitative result is given and samples are reported as
Positive or Negative.