Neuronal Nuclear Antibody – Anti Ma antibody
(specialist request only)
Limbic encephalitis Wide range of cerebellar symptoms
(especially older patients)
Please note: Approximately 78% of patients with anti Ma2
antibodies have associated tumours of the testis and up to 40% of
patients with cerebellar ataxia and lung tumours have this
antibody. Anti Ma2 is more common in young patients while anti Ma1
and Ma3 are more common in older patients who tend to exhibit a
wider range of cerebellar symptoms and tumours other than germ cell
Detection of autoantibodies against neuronal nuclei.
Request via ICE.
Assay performed as required.
It is essential to provide relevant clinical information.
No special preparation is required.
All samples are generally sent to referral
laboratory within 3 working days of receipt in the
laboratory. The assay is performed as required.
Serum in red top tube
Gold top (SST) tube will be accepted
Samples should be transported to the laboratory as soon as is
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Causes for Rejection
Unlabelled/inadequately labelled sample
Inadequately completed request form
Delay in sample reaching laboratory.
Results are reported as a titre.
All positives will be confirmed.
Additional tests may be performed depending on patterns seen or
clinical details. These may include anti Amphiphysin, anti
CV2/CRMP5, anti PNMA2 (Ma2/Ta), anti Tr, anti Hu, anti Ri and anti
Yo. Additional assays may be Immunofluorescence and/or Immunoblot