Neuronal Nuclear Antibody – Anti Ri antibody
(specialist request only)
Please note: Breast or small cell liver carcinoma (SCLC)
are found in 75% of cases, carcinomas of the ovaries, fallopian
tubes, bladder and cervix are present less frequently. Detection of
this antibody should prompt a search for an underlying tumour,
primarily breast or SCLC which may be absent or occult.
Detection of autoantibodies against neuronal nuclei of the
central nervous system only.
Request via ICE.
Assay performed as required.
It is essential to provide relevant clinical information.
No special preparation is required.
All samples are generally sent to referral
laboratory within 3 working days of receipt in the
laboratory. The assay is performed as required.
Serum in red top tube
Gold top (SST) tube will be accepted
Samples should be transported to the laboratory as soon as is
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Causes for Rejection
Unlabelled/inadequately labelled sample
Inadequately completed request form
Delay in sample reaching laboratory.
Qualitative result: reported as Positive or Negative.
Quantitative result: reported as a titre Normal Range
All positive samples are confirmed.
Additional tests may be performed depending on patterns seen or
clinical details. These may include anti Amphiphysin, anti
CV2/CRMP5, anti PNMA2 (Ma2/Ta), anti Tr, anti Hu, and anti Yo.
Additional assays may be Immunofluorescence and/or Immunoblot