NMDA Receptor Antibodies
NMDA, NMDAR, N-methyl-D-aspartate Glutamate
Specialist request only
Encephalitis of unknown origin
First found in young women with ovarian tumours and prominent
psychiatric symptoms, amnesias, seizures, dyskinesias, autonomic
dysfunction and decreased level of consciousness. Now also found in
both male and female patients (including children) without tumour.
With early diagnosis and treatment (immunotherapy and tumour
removal) patients often improve.
Detection of autoantibodies directed against a number of
subunits of the NMDA Receptor
Request via ICE
Assay performed weekly
It is essential to provide relevant clinical information.
All samples are generally sent to referral
laboratory within 3 working days of receipt in the
laboratory. The assay is performed daily; Samples are batched and
Samples should be transported to the laboratory as soon as is
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Causes for Rejection
Unlabelled/inadequately labelled sample
Inadequately completed request form
Delay in sample reaching laboratory
A qualitative result is given and samples are reported as
Positive or Negative.