Pathology Handbook

Ovary/Testis Steroid Cell Antibody

Clinical Indications

Premature ovarian failure

Addison's disease

Polyglandular autoimmunity

Please note: This assay includes the detection of antibodies to adrenal cortex; parathyroid gland; pituitary gland; ovary and testes. Autoantibodies against steroid producing cells are found in 50-70% of patients with Addison's disease; 30-70% of patients with premature ovarian failure; 60-80%of patients with autoimmune polyglandular disease (AGPS) Type 1; 40-80% of patients with AGPS type 2 and approximately 11% of patients with AGPS type 3.

Test Includes

Detection of IgG antibodies against cytochrome P450 enzymes

Request Form 

Request via ICE

Availability

Assay is performed twice weekly.

Specific Criteria

It is essential to provide relevant clinical information.

Patient Preparation

No special preparation is required.

Turnaround Time

All samples are generally sent to  referral laboratory within 3 working days of receipt in the laboratory. Samples are batched and the assay is performed twice weekly.

Specimen

Serum in red top tube

Gold top (SST) tube will be accepted

Volume

7 ml

Container

Vacutainer red top

Collection

Samples should be transported to the laboratory as soon as is practicably possible.

Lab Handling

Aliquot and store at 4-8°C prior to testing and at -20°C or below for up to 1 month after receipt.

Causes for Rejection

Unlabelled/inadequately labelled sample

Inadequately completed request form

Delay in sample reaching laboratory.

Reference Range

A qualitative result is given and samples are reported as Positive or Negative.