Pathology Handbook

Prothrombin gene PCR


PGP, FII PCR, Prothrombin gene mutation

Clinical Indications

Clinical / family history of thrombotic episodes

Please refer to Thrombophilia clinic or d/w Consultant haematologist BEFORE making request.

It is strongly suggested to request a Thrombophilia screen rather than this test in isolation even if investigating a known family history of prothrombin gene mutation 

Request Form 

Request via ICE


Mon - Fri 9AM to 4PM
Genetic testing will only be performed on one occasion.

Specific Criteria

Patient should be bled with minimal stasis

Patient Preparation


Turnaround Time

2-3 weeks (sent externally)


Fresh citrated Blood (within 2 hours of collection)


4.5 ml blue citrated blood


4.5 ml blue citrated bottles
Vacutainer blue top


Samples should be taken with minimal stasis and taken to the laboratory as soon as possible

Causes for Rejection

Underfilled, clotted or haemolysed samples

Reference Range

See patient test report