Purkinje Cell Antibodies – Anti Tr
(Specialist request only)
Please note: There is a strong link
between the presence of this antibody and paraneoplastic cerebellar
degeneration in patients with Hodgkin's disease (80%).
Detection of autoantibodies to antigens expressed in Purkinje
Request on ICE
Assay is performed weekly.
No special preparation is required.
It is essential to provide relevant clinical information.
All samples are generally sent to referral
laboratory within 3 working days of receipt in the
laboratory. Samples are batched and the assay is performed once per
Red top tube. Gold top tube will be accepted.
Samples should be transported to the laboratory as soon as is
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Causes for Rejection
Unlabelled/inadequately labelled sample.
Inadequately completed request form.
Delay in sample reaching laboratory.
Results are reported as a titre.
Additional tests may be performed depending on patterns seen or
clinical details. These may include anti Amphiphysin, anti
CV2/CRMP5, anti PNMA2 (Ma2/Ta), anti Ri, anti Hu, and anti Yo.
Additional assays may be Immunofluorescence and/or Immunoblot