Purkinje Cell Antibodies – Anti Yo
(Specialist request only)
Please note: Carcinoma of the ovary or
breast are found in 90% of cases. Other reported tumours include
those of the uterus, fallopian tube and lung. Apart from rare
exceptions, anti Yo antibodies occur with gynaecological cancers
and their presence warrants the search for an occult tumour.
Detection of autoantibodies against organelles in the cytoplasm
of Purkinje cells.
Request on ICE
Assay is performed weekly.
No special preparation is required.
It is essential to provide relevant clinical information.
All samples are generally sent to referral
laboratory within 3 working days of receipt in the
laboratory. Samples are batched and the assay is performed once per
Red top tube. Gold top tube will be accepted.
Samples should be transported to the laboratory as soon as is
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Causes for Rejection
Unlabelled/inadequately labelled sample.
Inadequately completed request form.
Delay in sample reaching laboratory.
Qualitative result: reported as Positive
Quantitative result: reported as a titre
Normal Range <1/200 All positive samples are confirmed.
Additional tests may be performed depending on patterns seen or
clinical details. These may include anti Amphiphysin, anti
CV2/CRMP5, anti PNMA2 (Ma2/Ta), anti Ri, anti Hu, and anti Tr.
Additional assays may be Immunofluorescence and/or Immunoblot