S-100, an acidic calcium-binding protein, is present
within cells of neuroendocrine origin. Recent studies suggest
S-100 has particular utility in staging of malignant melanoma, in
establishing prognosis, in evaluating treatment success and in
Circulating S-100 levels very sensitively detect
metastatic growth of malignant melanoma, particularly in stage IV
Request on ICE
Analysed by referral laboratory if specific criteria met.
Assessment and monitoring of patients with malignant
Serum in red-topped tube
SST samples CANNOT be used
Causes for Rejection
Not meeting specific criteria for analysis.
Less than 0.2
It has been shown that S-100 rises 3 months before clinical
signs of recurrence. A S100 level of <0.2 is a reassuring