Pathology Handbook

S-100

Synonyms

S100B

Clinical Indications

S-100, an acidic calcium-binding protein, is present within cells of neuroendocrine origin. Recent studies suggest S-100 has particular utility in staging of malignant melanoma, in establishing prognosis, in evaluating treatment success and in predicting relapse.

Circulating S-100 levels very sensitively detect metastatic growth of malignant melanoma, particularly in stage IV disease.

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Availability

Analysed by referral laboratory if specific criteria met.

Specific Criteria

Assessment and monitoring of patients with malignant melanoma.

Turnaround Time

2 weeks

Specimen

Serum in red-topped tube

SST samples CANNOT be used

Volume

2 ml

Container

Vacutainer red top

Causes for Rejection

Not meeting specific criteria for analysis.

Reference Range

Less than 0.2 μg/L              

Interpretation

It has been shown that S-100 rises 3 months before clinical signs of recurrence. A S100 level of <0.2 is a reassuring negative result.