Pathology Handbook

Skeletal Antibodies


Striated muscle antibodies

Clinical Indications

Myasthenia gravis


Polymyositis (rare)

Please note: This antibody is found in 25-40% of all patients with Myasthenia gravis, almost all (80-100%) have myasthenia with thymoma.

Test Includes

Detection of IgG antibodies to contractile elements of the striational antibodies.

Request Form 

Request via ICE.


Assay is performed as required.

Specific Criteria

It is essential to give relevant clinical information.

Patient Preparation

No special preparation is required.

Turnaround Time

All samples are generally sent to  referral laboratory within 3 working days of receipt in the laboratory. The assay is performed as required.


Red top tube. Gold top SST tube will be accepted.


7 ml


Vacutainer red top


Samples should be transported to the laboratory as soon as is practicably possible.

Lab Handling

Aliquot and store at 4-8°C prior to testing and at -20°C or below for up to 1 month after receipt.

Causes for Rejection

Unlabelled/inadequately labelled sample.

Inadequately completed request form.

Delay in sample reaching laboratory.

Reference Range

A qualitative result is given and samples are reported as Positive, Weak Positive or Negative.