Theophylline levels are required if i.v. aminophylline is being
considered for patients already taking oral theophylline
preparations, as serious toxic side effects may occur. Measurement
of theophylline levels may be helpful if no clinical improvement is
seen on increasing doses, in confirming toxicity and management of
the overdosed patient and in patients where compliance may be an
Request on ICE
Analysed if specific criteria met.
In management of theophylline overdose, levels may be measured
urgently under the following circumstances (please contact Clinical
(a) if there is doubt about the clinical severity of
(b) in all patients with severity grades 3 and 4.
Patient on i.v theophylline(aminophylline) or on ITU/HDU
Requested by Consultant Physician for patients on oral
theophylline where compliance may be an issue or if agreed with
Management of theophylline overdose (see above)
Samples should preferably be collected pre-dose.
Serum in yellow top (SST) tube
Causes for Rejection
Not meeting specific criteria for analysis.
Therapeutic range: 10 -20 mg/L
Healthy adults: 3 - 13 hours (reduced in smokers)