Pathology Handbook

TSH Receptor Antibodies

Synonyms

TRAB

TSHR

Clinical Indications

Thyroid disorders Grave's disease Suspected thyroid disorders in pregnancy.

Specialist request only

Please note: The primary test for the investigation of autoimmune thyroid disease is the detection of anti Thyroid Peroxidase (TPO) antibodies.

Test Includes

Detection of autoantibodies against Thyroid Stimulating Hormone Receptors.

Request Form 

Request via ICE

Availability

Assay performed as required.

Specific Criteria

It is essential to provide relevant clinical information.

Patient Preparation

No special preparation is required

Turnaround Time

All samples are generally sent to referral laboratory within 3 working days of receipt in the laboratory. The assay is performed as required.

Specimen

Serum in red top tube

Gold top (SST) tube will be accepted

Volume

7 ml

Container

Vacutainer red top

Collection

Samples should be transported to the laboratory as soon as is practicably possible.

Lab Handling

Aliquot and store at 4-8°C prior to testing and at -20°C or below for up to 1 month after receipt.

Causes for Rejection

Unlabelled/inadequately labelled sample

Inadequately completed request form

Delay in sample reaching laboratory.

Reference Range

A qualitative result is given and samples are reported as Positive or Negative.

This test does not differentiate between blocking and stimulating antibodies.