Very long chain fatty acids (VLCFA)
VLCFA, peroxisomal function tests
Plasma very long chain fatty acids (especially C26:0) are
elevated in peroxisomal disorders such as Adrenoleukodystrophy,
Refsum disease and Zellweger Syndrome. They may present with
profound neurological and metabolic problems in infancy or
neurological and adrenal problems in childhood and adult life.
Phytanic acid may also be raised in Refsum's disease.
C22, C24, C26, C24/C22 and C26/C22 ratios, phytanate and
Request on ICE
Requested by Consultants in paediatrics or if agreed with
It is important fasting samples are collected in children over
18 months old
Approximately 3 weeks
Plasma collected into lithium heparin tube
Minimum volume 0.2 mL
Samples should be transported to laboratory immediately.
Causes for Rejection
Not meeting specific criteria for analysis.
Delay in sample reaching laboratory
Patient not fasting.
Reference ranges are age-related
See laboratory report