Pathology Handbook

Vigabatrin

Synonyms

-

Clinical Indications

Vigabatrin is licensed for use as adjunctive therapy in patients with refractory partial seizures and for the treatment of infantile spasms. Vigabatrin is an antiepileptic drug which acts by irreversibly inhibiting gamma-aminobutyrate aminotransferase, the enzyme responsible for the breakdown of GABA. Vigabatrin blood levels are linearly related to drug dosage and there is little benefit in monitoring blood levels as a guide to dosage required

At present, serum Vigabatrin concentrations are useful in assessing compliance and evaluating risks of toxicity

Its use has declined following the discovery of visual field defects in 30% of patients treated with the drug

Request Form 

Request on ICE

Availability

On request

Specific Criteria

None

Patient Preparation

Collect immediately before next dose due (trough level)

Note duration of therapy, daily dose and time of last dose

Turnaround Time

Weekly

Specimen

Serum in yellow (SST) tube

Volume

1 mL

Container

Vacutainer gold top

Collection

Note duration of therapy, daily dose and time of last dose

Causes for Rejection

Unlabelled sample
Not meeting specific criteria for analysis. 

Reference Range

2-36 mg/L