Pathology Handbook

Voltage gated Calcium Channel Antibodies



Clinical Indications

(specialist request only)

Lambert-Eaton Syndrome (with or without small cell lung carcinoma) Cerebellar ataxia associated with small cell lung carcinoma (SCLC) Please note: Over 80% of patients with Lambert-Eaton Syndrome have antibodies. Up to 40% of patients with the syndrome have no obvious tumour at presentation, but tumours often become apparent over the next 4 years.

Test Includes

Detection of IgG antibodies against the presynaptic calcium channel on the nerve terminal.

Request Form 

Request via ICE.


Assay is performed weekly.

Specific Criteria

It is essential to provide relevant clinical information.

Patient Preparation

No special preparation is required.

Turnaround Time

All samples are generally sent to referral laboratory within 3 working days of receipt in the laboratory. Samples are batched and the assay is performed once per week.


Red top tube. Gold top tube will be accepted.


7 ml


Vacutainer red top


Samples should be transported to the laboratory as soon as is practicably possible.

Lab Handling

Aliquot and store at 4-8°C prior to testing and at -20°C or below for up to 1 month after receipt.

Causes for Rejection

Unlabelled/inadequately labelled sample.

Inadequately completed request form.

Delay in sample reaching laboratory.

Reference Range

Negative: <45 pM

Positive: >45 pM