Voltage gated Calcium Channel Antibodies
(specialist request only)
Lambert-Eaton Syndrome (with or without small cell lung
carcinoma) Cerebellar ataxia associated with small cell lung
carcinoma (SCLC) Please note: Over 80% of patients with
Lambert-Eaton Syndrome have antibodies. Up to 40% of patients with
the syndrome have no obvious tumour at presentation, but tumours
often become apparent over the next 4 years.
Detection of IgG antibodies against the presynaptic calcium
channel on the nerve terminal.
Request via ICE.
Assay is performed weekly.
It is essential to provide relevant clinical information.
No special preparation is required.
All samples are generally sent to referral
laboratory within 3 working days of receipt in the
laboratory. Samples are batched and the assay is performed once per
Red top tube. Gold top tube will be accepted.
Samples should be transported to the laboratory as soon as is
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Causes for Rejection
Unlabelled/inadequately labelled sample.
Inadequately completed request form.
Delay in sample reaching laboratory.
Negative: <45 pM
Positive: >45 pM