Pathology Handbook

Voltage Gated Potassium Channel Antibodies



Clinical Indications

(specialist request only)

Acquired neuromyotonia Limbic encephalitis-like syndromes

Please note: These may be associated with thymoma or small cell lung carcinoma (SCLC).

Test Includes

Detection of IgG antibodies against the presynaptic potassium channel on the nerve terminal.

Request Form 

Request via ICE.


Assay is performed monthly.

Specific Criteria

It is essential to provide relevant clinical information.

Patient Preparation

No special preparation is required.

Turnaround Time

All samples are generally sent to referral laboratory within 3 working days of receipt in the laboratory. Samples are batched and the assay is performed monthly.


Red top tube. Gold top tube will be accepted.


7 ml


Vacutainer red top 


Samples should be transported to the laboratory as soon as is practicably possible.

Lab Handling

Aliquot and store at 4-8°C prior to testing and at -20°C or below for up to 1 month after receipt.

Causes for Rejection

Unlabelled/inadequately labelled sample.

Inadequately completed request form.

Delay in sample reaching laboratory.

Reference Range

  Negative: <100 pM

  Positive:  >100 pM