Voltage Gated Potassium Channel Antibodies
(specialist request only)
Acquired neuromyotonia Limbic encephalitis-like syndromes
Please note: These may be associated with thymoma or small
cell lung carcinoma (SCLC).
Detection of IgG antibodies against the presynaptic potassium
channel on the nerve terminal.
Request via ICE.
Assay is performed monthly.
It is essential to provide relevant clinical information.
No special preparation is required.
All samples are generally sent to referral
laboratory within 3 working days of receipt in the
laboratory. Samples are batched and the assay is performed
Red top tube. Gold top tube will be accepted.
Samples should be transported to the laboratory as soon as is
Aliquot and store at 4-8°C prior to testing and at -20°C or
below for up to 1 month after receipt.
Causes for Rejection
Unlabelled/inadequately labelled sample.
Inadequately completed request form.
Delay in sample reaching laboratory.
Negative: <100 pM
Positive: >100 pM